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目的了解手足口病大规模流行之前儿童的肠道病毒71型(EV71)感染率和抗体水平。方法以常州市2006年采集的252名1～5岁健康儿童血清为研究对象,采用中和试验测定血清的EV71中和抗体,以中和抗体阳性作为既往感染标志物。结果 1～5岁儿童EV71平均感染率为32.9%,1～3岁组感染率为9.8%～22.4%,4岁组和5岁组的感染率为43.5%和79.5%,分别与1～3岁组感染率(14.38%)进行比较,差异均有统计学意义。中和抗体几何平均滴度(GMT)在1～3岁组为4.9～8.8,4岁组和5岁组分别为21.8和147.5,组间差异有统计学意义。结论早在2008年全国大规模流行之前EV71在该地区已有一定程度的传播。
Objective To understand the prevalence and antibody level of Enterovirus 71 (EV71) in children before the HFMD pandemic. Methods Serum samples from 252 healthy children aged 1-5 years old collected in Changzhou City in 2006 were used as neutralizing antibodies to neutralize EV71 antibody. Neutralizing antibody was used as a marker of past infection. Results The average infection rate of EV71 in children aged 1 ~ 5 years was 32.9%, the infection rate in 1 ~ 3 years old group was 9.8% ~ 22.4%, and the infection rates in 4 years old group and 5 years old group were 43.5% and 79.5% The infection rate of the aged group (14.38%) were compared, the differences were statistically significant. The mean geometric mean antibody titer (GMT) of neutralizing antibodies ranged from 4.9 to 8.8 in the age group of 1 to 3 years old and 21.8 and 147.5 years in the 4 and 5 years old groups, respectively. There was significant difference between the two groups. Conclusion As early as 2008 before the national pandemic EV71 in the region has a certain degree of spread.