目前，临床对肝纤维化或肝硬化的确诊仍以肝穿活体组织检查为主，但它有创伤性，而且又难以动态观察。层粘连蛋白（ｌａｍｉｎｉｎ，Ｌｎ）是细胞外间质中的一种非胶原性结构蛋白。在肝内主要由内皮细胞、肝细胞及贮脂细胞合成，它是基底膜的一种主要成分。正常人血清中Ｌｎ的 At present, the clinical diagnosis of liver fibrosis or cirrhosis is still liver biopsy-based, but it is traumatic, but also difficult to dynamically observe. Laminin (laminin, Ln) is a non-collagenous structural protein in the extracellular matrix. In the liver mainly by the endothelial cells, liver cells and fat storage cells synthesis, it is a major component of the basement membrane. Normal human serum Ln