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目的:观察维吾尔族男性急性冠状动脉综合征(ACS)患者血清脂蛋白(a)[LP(a)]、血浆纤溶酶原激活抑制物-Ⅰ(PAI-Ⅰ)及血浆纤维蛋白原(Fg)水平变化并分析其相关性。方法:维吾尔族男性119例,分为2组: ACS组66例,对照组53例;分别测定其血清LP(a)、血浆PAI-Ⅰ和血浆Fg水平。结果:ACS组、对照组血清LP (a)分别为(422．323±201．685)、(146．60±80．984)mmol／L;2组血浆PAI-Ⅰ含量吸收度(A值)分别为(1．276 ±0．831)和(0．369±0．418);血浆Fg水平分别是(4．688±0．970)、(3．515±0．507)g／L,2组间差异均有统计学意义(P<0．05)。将119例研究对象,按LP(a)分为≤300 mmol／L组和>300 mmol／L,比较2组PAI-Ⅰ含量和 Fg水平:LP(a)>300 mmol／L组(55例)A值为(1．182±0．842),Fg为(4．563±0．980)g／L;LP(a)≤300 mmol／ L组(64例),A值为(0．605±0．691),Fg为(3．824±0．864)g／L,经秩和检验2组间差异具有统计学意义(P< 0．01)。血清LP(a)与血浆PAI-Ⅰ含量相关分析,r=0．427,P<0．01;血清LP(a)与血浆Fg进行相关分析,r =0．441,P<0．01。结论:血清LP(a)、血浆PAI-Ⅰ和血浆Fg水平在维吾尔族男性ACS患者中明显增高;血清 LP(a)水平高者血浆PAI-Ⅰ及Fg亦有较高水平,血清LP(a)水平与血浆PAI-Ⅰ、Fg水平间呈正相关。维吾尔族男性LP(a)、PAI-Ⅰ和Fg水平增高与其冠心病临床事件的发生有关。
Objective: To observe the changes of serum lipoprotein (a) [LP (a)], plasma plasminogen activator inhibitor-Ⅰ (PAI-Ⅰ) and plasma fibrinogen (Fg) in Uygur male patients with acute coronary syndrome (ACS) ) Level changes and analyze their relevance. Methods: 119 male Uighur patients were divided into two groups: ACS group (66 cases) and control group (53 cases). Serum LP (a), plasma PAI-Ⅰ and plasma Fg levels were measured respectively. Results: Serum LP (a) of ACS group and control group were (422.323 ± 201.685) and (146.60 ± 80.984) mmol / L, respectively; PAI- (1.276 ± 0.831) and (0.369 ± 0.418), respectively. The plasma Fg levels were (4.688 ± 0.970) and (3.515 ± 0.507) g / L, The differences between the two groups were statistically significant (P <0.05). 119 patients were divided into three groups according to LP (a): ≤300 mmol / L and> 300 mmol / L, PAI-Ⅰcontent and Fg level in two groups were compared: LP (a)> 300 mmol / L ) A value was (1.182 ± 0.842), Fg was (4.563 ± 0.980) g / L; LP (a) ≤300 mmol / L group (64 cases) 605 ± 0.691) and Fg was (3.824 ± 0.864) g / L, respectively. The difference between the two groups was statistically significant (P <0.01). The correlation analysis between serum LP (a) and plasma PAI-Ⅰ content was r = 0.427, P <0.01. The correlation analysis between serum LP (a) and plasma Fg was r = 0.441, P <0.01. Conclusions: Serum LP (a), plasma PAI-I and plasma Fg level were significantly higher in Uygur men with ACS. Serum LP (a) levels were also higher in plasma PAI-I and Fg, serum LP ) Levels and plasma levels of PAI-Ⅰ, Fg was positively correlated. The Uygur male LP (a), PAI-Ⅰ and Fg levels increased with the occurrence of coronary heart disease clinical events.