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目的:探讨急诊救治野生菌中毒的体会与经验,比较抗胆碱类药物长托宁与阿托品对野生菌中毒的治疗效果与安全性。方法:选择于2011年5月～2012年5月在我院急诊救治的野生菌中毒患者81例,随机分为长托宁组和阿托品组,两组患者均给予禁食、洗胃、导尿、导泻等对症治疗,对照组40例,根据中毒程度,给予适量阿托品治疗,观察组41里,按中毒程度给予适量长托宁治疗,对比两组患者的治疗有效率、症状消失时间、乙酰胆碱酯酶恢复时间和药物中毒率。结果:长托宁组患者与阿托品组患者的治疗有效率分别为95.1%(39/41)和82.5%(33/40),症状消失时间分别为8.1±5.4h和19.4±10.0h,乙酰胆碱酯酶恢复时间分别为10.9±9.4h和22.3±12.4h,药物中毒率分别为4.8%(2/41)和17.5%(7/40),组间差异显著,具统计学意义(P<0.05)。结论:治疗急性野生菌中毒的关键在于尽快彻底洗胃,使用足量的抗胆碱、胆碱酯酶复活剂,长托宁对急性野生球菌中毒的治疗效果较阿托品更好,值得临床推广。
Objective: To explore the experience and experience of emergency treatment of wild mushroom poisoning, and to compare the therapeutic effect and safety of anticholinergic antitussive and atropine on wild mushroom poisoning. Methods: From May 2011 to May 2012, 81 patients with wild-type poisoning who were treated in our hospital for emergency treatment were randomly divided into a long-acting group and atropine group. Both groups were given fasting, gastric lavage and catheterization , Catharsis and other symptomatic treatment, the control group of 40 cases, according to the degree of poisoning, giving appropriate amount of atropine treatment, the observation group 41, according to the degree of poisoning given amount of penehyclidine treatment, the two groups were compared the treatment efficiency, symptom disappear time, acetylcholine Esterase recovery time and drug toxicity rate. Results: The response rates of the penehyclidine group and the atropine group were 95.1% (39/41) and 82.5% (33/40), respectively. The duration of symptom disappearance was 8.1 ± 5.4 h and 19.4 ± 10.0 h, respectively. Acetylcholinesterase The recovery time was 10.9 ± 9.4 h and 22.3 ± 12.4 h, respectively. The rates of drug poisoning were 4.8% (2/41) and 17.5% (7/40), respectively. There was significant difference between the two groups (P <0.05) . Conclusion: The key to the treatment of acute wild bacterial poisoning is to thoroughly gastric lavage as soon as possible. The use of adequate anticholinergic and cholinesterase resuscitators and the long-acting treatment of acute wild cocci poisoning is more effective than atropine, which is worthy of clinical promotion.