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纳米红色元素硒是以蛋白质为分散剂的元素硒的纳米粒子,粒径在60nm 以内。体外研究证实,纳米红色元素硒能够与谷胱甘肽反应,其反应能力约为亚硒酸钠的1/20至1/10。急性毒性实验证实以口服硒元素的量计,纳米红色元素硒的LD50 = 112.98(89.95～141.90)m g/kgBW,亚硒酸钠的LD50= 15.72(13.38～18.47)m g/kgBW,显示出纳米红色元素硒的毒性低。生物利用性试验证实:小鼠分别口服纳米红色元素硒和亚硒酸钠(Se 50μg/kg BW)30天,与对照组比,2种硒都能显著提高小鼠血硒和肝硒浓度,血中谷胱甘肽过氧化物酶活性升高。这说明纳米红色元素硒能被小鼠较好利用
Nano-red elemental selenium is a protein-based dispersant elemental selenium nanoparticles, particle size within 60nm. In vitro studies confirmed that nano-red elemental selenium can react with glutathione and its reactivity is about 1/20 to 1/10 of that of sodium selenite. Acute toxicity tests confirmed that LD50 = 112.98 (89.95 ~ 141.90) mg / kgBW and sodium selenite LD50 = 15.72 (13.38 ~ 18.47) mg / kgBW for the red selenium element based on the amount of oral selenium. Elemental selenium is less toxic. Bioavailability test confirmed that: mice were orally administered nano-red elemental selenium and sodium selenite (Se 50μg / kg BW) for 30 days, compared with the control group, two kinds of selenium can significantly increase the blood selenium and liver selenium concentrations, Increased glutathione peroxidase activity in the blood. This shows that nano-red elemental selenium can be better use of mice