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本文用家兔静脉给药,以碘化钠(~(131)I)溶液作对照液,对比研究了在水相中含(~(131)I)碘化钠脂质体与含有磷脂共价结合(~(131)I)脂质体在家兔体内分布和代谢本实验水相中含(~131I)碘化钠脂质体的粒度14%≤1.0μm,95%≤2.0μm;共价结合(~(131)I)脂质体粒度为13%≤1.0μ,93%≤2.0μm。体外溶出和体内分布的实验结果指出,在水相中含(~(131)I)碘化钠脂质体的体外释放速度为2%/小时,而共价结合碘脂质体为0.15%/小时;所有制剂在体内开始的40～60小时,(~(131)I)的消除代谢动力学出现较快的复指数过程但随后变慢,这是由于碘参与了甲状腺内循环[等渗碘溶液和水相中包(~(131)I)脂质体]和肝循环[共价
In this paper, rabbit intravenous administration of sodium iodide (~ (131) I) solution as a control solution, comparative study of aqueous phase containing (~ (131) I) sodium iodide liposomes and containing phospholipid covalent The distribution and metabolism of (~ (131) I) liposomes in rabbitsIn this experiment, the aqueous phase containing (~ 131 I) sodium iodide liposomes had a particle size of 14% ≤1.0μm and 95% ≤2.0μm; covalent The bound (~ (131) I) liposomes were 13% ≤1.0μ and 93% ≤2.0μm. In vitro dissolution and in vivo distribution of the experimental results indicate that the in vitro release rate of (~ (131) I) sodium iodide liposomes is 2% / hr in the aqueous phase and that of covalently bound iodo liposomes is 0.15% Hour; all preparations started 40 to 60 hours in vivo, (~ (131) I) had a faster exponential process of elimination kinetics but then slowed down due to the involvement of iodine in the thyroid gland circulation [isotonic iodine The solution and aqueous phase contained (~ (131) I) liposomes] and hepatic circulation [covalently