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非诺贝特为烟酸类衍生物,可有效降低血三酰甘油、极低密度脂蛋白,升高高密度脂蛋白,在临床广泛应用于高脂血症。说明书中不良反应项下提及胃肠道反应,皮肤过敏反应,肝、肾功能损害以及对肌肉的损害,罕见横纹肌溶解。现将口服非诺贝特胶囊引起横纹肌溶解及肝损伤患者1例报道如下。
Fenofibrate as nicotinic acid derivatives, can effectively reduce blood triglyceride, very low density lipoprotein, high density lipoprotein, widely used in clinical hyperlipidemia. Mentioned in the manual adverse reactions under the gastrointestinal tract reactions, skin allergies, liver and kidney dysfunction and damage to the muscle, rare rhabdomyolysis. Now oral fenofibrate capsules caused rhabdomyolysis and liver injury in 1 patient reported as follows.