白细胞介素4(C589T)基因多态性与胆石病的相关性研究

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目的探讨白细胞介素4(IL-4)(C589T)基因多态性与胆石病发病例因素的相关性.方法采用聚合酶链式反应-限制性片段长度多态性分析(PCR-RFLP)技术对中国南京地区81例胆囊结石患者和41例胆管结石患者进行IL-4(C589T)基因型分析.结果胆囊结石组与胆管结石组患者IL-4(C589T)基因型频率和等位基因频率有显著性差异(CC分别为11.1%和48.8%、CT分别为34.6%和36.6%、TT分别为54.3%和14.6%、C分别为28.4%和67.1%、T分别为71.6%和32.9%).结论 IL-4(C589T)基因多态性与胆管结石的形成存在相关性,与胆囊结石不存在相关性.
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