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目的:探讨重组生物酵母乙肝疫苗不同免疫程式的免疫效果。对1620名人群进行酵母乙肝疫苗免疫接种,通过不同免疫时间、性别与年龄来反应其检测抗-HBs阳性情况。结果:1620名观察对象经过检测后,抗-HBs阳性人数为790名,检出率为48.8%,其中首次接种后第1个月、3个月和6个月的抗-HBs阳转率分别为20.0%、45.5%和94.7%,三个时间段前后差异都有统计学意义(P<0.05)。不同免疫后时间段的女性抗-HBs阳性率都明显高于男性(P<0.05)。不同年龄之间的抗-HBs阳转率比较无显著性差异(P>0.05)。结论:酵母重组乙肝疫苗对青年人群具有良好的近期免疫效果,值得推广使用。
Objective: To investigate the immune effect of different immunization programs of recombinant yeast. 1620 population of yeast hepatitis B vaccine immunization, by different immune time, sex and age to respond to its detection of anti-HBs positive. Results: After the detection of 1620 subjects, the positive number of anti-HBs was 790, with a detection rate of 48.8%. The anti-HBs positive rates in the first month, the third month and the sixth month after the first vaccination were respectively 20.0%, 45.5% and 94.7%, respectively, with significant difference between the three time periods (P <0.05). The positive rates of anti-HBs in different time period after immunization were significantly higher than those in male (P <0.05). There was no significant difference in anti-HBs positive rate among different ages (P> 0.05). Conclusion: Yeast recombinant hepatitis B vaccine has a good recent immunization effect on young people and is worth promoting.