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[目的]探讨单侧肾上腺皮质结节增生性原发性醛固酮增多症的临床特点,提高诊治水平。[方法]对27例经手术及病理学确诊的单侧肾上腺皮质结节增生性原发性醛固酮增多症患者的资料进行回顾性分析。[结果]术后随访20例患者,18例患者术后6个月内血压恢复正常;2例6个月后血压控制不理想,其中1例需2种以上降压药物联合降压。[结论]部分单侧肾上腺皮质结节增生性原发性醛固酮增多症的定性诊断需要反复检测血浆醛固酮及肾素等,CT及肾上腺静脉采血是其术前分型定侧诊断的重要手段。
[Objective] To explore the clinical features of primary aldosteronism with unilateral adrenocortical nodules and to improve the diagnosis and treatment. [Methods] The data of 27 patients with proliferative primary aldosteronism of unilateral adrenal cortex nodules confirmed by operation and pathology were retrospectively analyzed. [Results] Twenty patients were followed up, and 18 patients returned to normal within 6 months after operation. The blood pressure was not satisfactory in 2 patients after 6 months. One patient needed more than two antihypertensive drugs in combination with antihypertensive drugs. [Conclusion] The qualitative diagnosis of hyperproliferative primary aldosteronism in some unilateral adrenocortical nodules requires repeated detection of plasma aldosterone and renin, and CT and adrenal vein blood sampling are important methods for preoperative diagnosis of primary aldosteronism.