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用辣椒素耗竭豚鼠离体支气管感觉神经肽（ＳＮＰｓ）后，观察支气管对缺氧及不同化学激动剂的反应变化。结果发现支气管对１０％ 氧产生的舒张反应显著增强（Ｐ＜ ０．０５）； 对１０－ ６ ～２×１０－ ４ ｍ ｏｌ／Ｌ组胺（Ｈｉｓ）及１０－ ５ ～１０－ ４ ｍ ｏｌ／Ｌ５－羟色胺（５－ＨＴ） 的收缩反应显著降低（均为Ｐ＜ ０．０５）， 而对１０－ ６ ～２×１０－ ４ ｍ ｏｌ／Ｌ乙酰胆碱（ Ａｃｈ） 的收缩反应和异丙肾上腺素 （Ｉｓｏｐ） 的舒张反应均无明显改变。提示支气管Ｃ－感觉神经所释放的ＳＮＰｓ降低支气管对缺氧的反应性，增强对Ｈｉｓ和５－ＨＴ的反应性， 但不影响其对Ｉｓｏｐ 和Ａｃｈ 的反应性。
Bronchial responses to hypoxia and different chemical agonists were observed after capsaicin-depleted guinea pig sensory neuropeptides (SNPs) in vitro. The results showed that the bronchial diastolic response to 10% oxygen was significantly increased (P <0.05). The effects of 10-6 ~ 2 × 10-4 mol / L histamine (His) and 10-5 ~ 10-4 mol / L-serotonin (5-HT) was significantly decreased (all P <0.05), while contractile responses to acetylcholine (Ach) of 10 -6 to 2 × 10 -4 mol / There was no significant change in the diastolic response to Isop. It is suggested that SNPs released by bronchial C-sensory nerves reduce bronchial responsiveness to hypoxia and enhance reactivity to His and 5-HT, but do not affect their reactivity to Isop and Ach.