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目的：评价采用环磷酰胺、阿霉素、顺铂（ＣＡＰ方案）联合治疗晚期乳腺癌的疗效。方法：晚期乳腺癌３０例，其中２８例为初治（包括以前用过辅助化疗１１例），１７例有２处以上部位转移。环磷酰胺５００ｍｇ／ｍ２，静冲，ｄ１，８；阿霉素４０ｍｇ／ｍ２，静冲，ｄ１；顺铂３０ｍｇ／ｍ２，静滴，ｄ３，４，５，２１天为一周期。结果：总有效率７０％（２１／３０），完全缓解率１０％（３／３０），中位缓解期６月，中位生存期１４．５月。对软组织转移有效率为６８％（１５／２２），肺转移有效率为４／７，胸膜、肝、骨转移有效率分别为２／３、１／２、２／２。本组病人有不同程度胃肠反应，其中Ⅲ度占５７％。白细胞减少（Ⅲ度）占４３％。未发现肾毒性。结论：ＣＡＰ方案是治疗晚期乳腺癌的较好方案。
Objective: To evaluate the efficacy of combination chemotherapy with cyclophosphamide, doxorubicin, and cisplatin (CAP regimen) in the treatment of advanced breast cancer. Methods: Thirty patients with advanced breast cancer, of which 28 cases were initially treated (including 11 cases of previously used adjuvant chemotherapy), 17 cases had more than 2 sites metastasis. Cyclophosphamide 500mg/m2, static flush, d1, 8; doxorubicin 40mg/m2, static flush, d1; cisplatin 30mg/m2, intravenous infusion, d3, 4, 5, 21 days for a cycle. Results: The total effective rate was 70% (21/30), the complete remission rate was 10% (3/30), the median remission period was 6 months, and the median survival period was 14.5 months. The effective rate of soft tissue transfer was 68% (15/22), the effective rate of lung metastasis was 4/7, and the effective rates of pleural, liver, and bone metastases were 2/3, 1/2, and 2/2, respectively. This group of patients have different degrees of gastrointestinal reactions, including III degree of 57%. Leukopenia (III degree) accounted for 43%. No nephrotoxicity was found. Conclusion: The CAP regimen is a better treatment for advanced breast cancer.