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男子射精后的最初精浆类似凝胶状,精子含于其中或附于表面,无法自由游动。但随后即产生一种自发液化过程使凝胶液化,此时精子即可在女性生殖道里自由游动。如果设法阻止最初状态的精液液化,精子游动性能受到损坏,丧失穿透宫颈粘液的能力,将有可能导致不育。因此认为保持精浆凝胶状态对阴道避孕法的发展有相当的意义。从此观点出发,作者应用体外评价法筛选了101种天然的和合成的酶抑制剂以及非活化剂。筛选用的精液由加尔哥达大学医院获得。为了精确的证明化合物对精浆液化时间的效应,试验时只应用有正常液化时间的精液样品。应用Tauber等介绍的袋方法(bag method)测定室温下精浆液化时间。液化时间每3分钟测定一次直至精浆完全液化为止。如果检测2小时后精浆仍未液化,则对该化合物尚须进行杀
After the first ejaculation in men, the seminal plasma resembles a gelatinous sperm contained in or attached to the surface, unable to swim freely. But then there is a spontaneous liquefaction process that liquefies the gel, at which point the sperm can swim freely in the female reproductive tract. If you try to prevent the liquefaction of semen in the initial state, sperm motility damage, the loss of the ability to penetrate the cervical mucus, it may lead to infertility. So that the maintenance of the state of seminal plasma on the development of vaginal birth has a considerable significance. From this point of view, the authors used in vitro evaluation of 101 natural and synthetic enzyme inhibitors and non-activators. Screening semen was obtained from the University of Gardaland Hospital. To accurately demonstrate the effect of compounds on seminal liquefaction time, only semen samples with normal liquefaction times should be used in the assay. The seminal liquefaction time at room temperature was determined using the bag method described by Tauber et al. The liquefaction time is measured every 3 minutes until the seminal plasma is completely liquefied. If the seminal plasma is still not liquefied after 2 hours of testing, kill the compound