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例1,患者女,85岁。全身泛发青紫色丘疹、结节2个月,无自觉症状。例2,患者女,33岁。左侧下腹部出现一紫红色结节3个月,质地硬,活动度差,边界尚清,压痛(+)。皮损组织病理示:两例组织学表现基本一致,表皮未见异常,真皮全层见中等大小、形态较一致的幼稚肿瘤细胞弥漫或灶状浸润,肿瘤组织与表皮之间形成无浸润带,肿瘤细胞核大,深染,不规则,核仁不明显。免疫病理学示:两例均表现CD4,CD56,CD123,CD31(+),CD3,CD20,CD117,MPO,EBER(-)。诊断:母细胞性浆细胞样树突细胞肿瘤。两例患者分别于确诊后1个月及8个月死亡。
Example 1, female patient, 85 years old. Generalized bluish-purple papules, nodules 2 months, no symptoms. Example 2, female patient, 33 years old. The left lower abdomen appears a purple red nodules 3 months, hard texture, poor mobility, the boundary is clear, tenderness (+). Histopathological examination of the lesion showed that the histological findings of the two cases were basically the same, no abnormality was found in the epidermis, moderate or full size dermis, infiltrative or focal infiltration of the naive tumor cells in the same form, no infiltration zone formed between the tumor tissue and the epidermis, Large tumor nuclei, stained, irregular, not obvious nucleolus. Immunopathology showed that CD4, CD56, CD123, CD31 (+), CD3, CD20, CD117, MPO and EBER (-) were expressed in both cases. Diagnosis: Bustular plasmacytoid dendritic cell tumor. Two patients died at 1 month and 8 months after diagnosis, respectively.