论文部分内容阅读
目的 :寻找防腐剂在药物中的简单、快速、准确的检测方法 ;方法 :用梯度洗脱液相色谱法测定口服中成药制剂中防腐剂含量。结果 :此法能同时检测 5种常用的防腐剂 :山梨酸、苯甲酸、水杨酸、对羟基苯甲酸的甲酯和乙酯。应用此法对 10 9个不同口服液样本进行检测 ,发现有接近 80 %的样本含有防腐剂。结论 :实验证明此法准确性、重复性均良好。
Objective : To find a simple, rapid and accurate detection method of preservatives in medicine; Method : To determine the content of preservatives in oral Chinese medicine preparations by gradient elution liquid chromatography. Results : This method can simultaneously detect 5 kinds of commonly used preservatives: sorbic acid, benzoic acid, salicylic acid, methyl and ethyl esters of p-hydroxybenzoic acid. Using this method to detect 109 different oral liquid samples, it was found that nearly 80% of the samples contained preservatives. Conclusion : Experiments show that this method has good accuracy and repeatability.