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蛋白C(PC)是新近发现的血浆抗凝因子,在高凝状态性疾病和血栓性疾病的发生发展中起重要作用。PC在体内被血栓调节蛋白(TM)和凝血酶活化后形成活化型PC(APC)介导因子Ⅴa/Ⅷa的灭活并促使血管内皮释放纤溶酶原活化素(PA),发挥抗凝血和促纤溶作用。同时,PC虽不是一种时相反应蛋白,但机体在某些病理状态时可发生显著变化,故可用于临床诊断疾病、观察病情变化及判断预后。国内对PC活性在人群中的分布、正常值及其在各疾病中的病理意义尚缺乏报道。为此,我们在纯化人血
Protein C (PC) is a newly discovered plasma anticoagulant factor that plays an important role in the development of hypercoagulable and thrombotic diseases. PC is activated by thrombomodulin (TM) and thrombin in vivo to form activated PC (APC) -mediated factor νa / Ⅷa inactivation and promote the release of plasminogen activator (PA) from the vascular endothelium to exert anti-coagulation And promote fibrinolysis. At the same time, although PC is not a phase reaction protein, but the body in some pathological conditions can be significant changes, it can be used for clinical diagnosis of disease, observation of the condition changes and prognosis. Domestic PC activity in the population distribution, normal and its pathological significance in each disease is still lack of coverage. For this reason, we are purifying human blood