论文部分内容阅读
一、致畸试验用杀虫脒25％水剂、杀虫脒盐酸盐(含量89.4％)以及杀虫脒代谢产物4-氯-邻甲苯胺在Wistar大鼠身上做致畸试验。给药组包括25％水剂0、8、40、l00mg/kg,纯品125mg/kg,4-氯-邻甲苯胺100mg/kg以及对照组(不给药),于孕期6～15天连续口喂给药,20天处死,检查吸收、活胎、死胎。活胎鼠部分以茜素红染色后检查骨骼,部分以包氏液固定后作内脏切片检查。实验结果:杀虫眯水剂l00mg/kg和纯品125mg/kg对孕鼠增重有明显影响,后者引
First, the teratogenicity test Chlordiazate 25% aqueous solution, chlordimeform hydrochloride (content of 89.4%), and chlordimeform metabolites 4-chloro-o-toluidine in Wistar rats who teratogenicity test. The treatment group consisted of 25% aqueous solution of 0, 8, 40, l00mg / kg, pure 125mg / kg, 4-chloro-o-toluidine 100mg / kg and the control group Oral administration, 20 days sacrifice, check absorption, live fetus, stillbirth. Live fetus part of alizarin red stained bone check, part of the package fluid fixation after visceral biopsy. Experimental results: Insecticides watering agent l00mg / kg and pure 125mg / kg on pregnant rats weight gain significantly, the latter cited