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目的 本实验拟通过对郎格罕氏细胞在口腔鳞状细胞癌中的分布情况进行研究 ,从免疫学上研究口腔鳞状细胞癌的发病机制 ,以期在免疫学上为口腔鳞状细胞癌的防治提供理论基础。方法 本研究采用 S— 10 0蛋白特异性标记郎格罕氏细胞 ,以免疫组织化学 PAP方法对 2 5例口腔鳞状细胞癌的上皮及间质内郎格罕氏细胞分布特点进行观察 ,计算郎格罕氏细胞出现频率。结果 口腔鳞状细胞癌病损组织中郎格罕氏细胞数目为正常口腔粘膜组织的 19.5倍。在细胞分布上 ,正常口腔粘膜组织中郎格罕氏细胞紧贴基底细胞层 ,而病变组织中的郎格罕氏细胞则散布于癌巢和癌巢间的淋巴细胞中。所有组织标本中均有淋巴细胞浸润带出现。结论 本研究结果表明 :1.癌上皮内郎格罕氏细胞与淋巴细胞相伴浸润 ,关系密切 ;2 .间质内郎格罕氏细胞与淋巴细胞相伴浸润 ,关系密切 ;3.郎格罕氏细胞可能为抗原递呈细胞 ,在鳞状细胞癌免疫反应启动和调节中可能起着关键作用
Objective To study the distribution of Langerhans cells in oral squamous cell carcinoma and to study the pathogenesis of oral squamous cell carcinoma from the perspective of immunology in order to study the immunological characteristics of oral squamous cell carcinoma Prevention provides a theoretical basis. Methods In this study, the specificity of S-10 protein was used to label human Langerhans cells. The distribution of Langerhans cells in epithelial and interstitial of 25 cases of oral squamous cell carcinoma was observed by immunohistochemical PAP method. The frequency of Langerhans cells. Results The number of Langerhans cells in oral squamous cell carcinoma tissues was 19.5 times of normal oral mucosa. In the cell distribution, normal oral mucosa of Langerhans cells close to the basal cell layer, while the diseased tissue of Langerhans cells are scattered in the cancer nest and cancer nests in lymphocytes. All tissue samples have lymphocyte infiltration zone appear. Conclusions The results of this study indicate that: 1. The relationship between the infiltration of intracranial Langerhans cells and lymphocytes is closely related; 2. The interstitial infiltration of Langerhans cells and lymphocytes is closely related; Cells may be antigen presenting cells that may play a key role in the initiation and regulation of immune responses in squamous cell carcinomas