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在婴儿以及免疫功能低下的成人和老人中,呼吸道合胞病毒感染仍然是一个严重的健康问题,没有有效的可利用的疫苗的原因是由于存在一些障碍:非复制性呼吸道合胞病毒疫苗可引起过度的Th2型应答,增强了疫苗接种者自然感染呼吸道合胞病毒而引起的呼吸系统疾病。作者以前发现含有Toll样受体4配体单磷酰类脂A的重组呼吸道合胞病毒病毒体可加强疫苗诱导的免疫应答,并且使免疫应答倾向于Th1型应答,也就不会引起呼吸系统疾病,由于黏膜免疫接种是诱导呼吸道合胞病毒特
Respiratory syncytial virus infection remains a serious health problem in infants and immunocompromised adults and the elderly, and the reason that there is no effective available vaccine is due to a number of obstacles: Non-replicating RSV vaccines can cause Excessive Th2 response enhances respiratory disease caused by natural infection of respiratory syncytial virus in vaccinated individuals. The authors previously found that recombinant respiratory syncytial virus virosomes containing the Toll-like receptor 4 ligand monophosphoryl lipid A potentiate a vaccine-induced immune response and tend to predispose the immune response to a Th1-type response without causing the respiratory system Disease, due to mucosal immunization is induced respiratory syncytial virus special