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目的研究假丝酵母菌属的临床分布及其对抗真菌药物的敏感性。方法假丝酵母菌属分离培养采用科玛嘉显色培养基,药敏试验采用K-B法,观察111株假丝酵母菌属对益康唑(ECO)、制霉菌素(NYS)、伊曲康唑(ITR)、酮康唑(KET)、氟康唑(FLU)、5-氟胞嘧啶(FCT)、两性霉素B(AMB)的敏感性。结果111株假丝酵母菌属中,以白色假丝酵母菌最常见,占70.27%,其次为热带假丝酵母菌占21.62%,其他假丝酵母菌占8.1%;假丝酵母菌属感染的原发疾病依次为肿瘤、呼吸系统、循环系统、消化系统、血液系统、内分泌、泌尿系统疾病;假丝酵母菌属对抗真菌药物的敏感性依次为制霉菌素、两性霉素B、伊曲康唑、5-氟胞嘧啶、酮康唑、氟康唑、益康唑。结论真菌感染与原发病及老龄化等因素密切相关;合理使用抗菌药物、提高机体免疫力是预防住院患者真菌感染的主要措施。
Objective To study the clinical distribution of Candida and its sensitivity to antifungal agents. Methods The Candida species were isolated and cultured using Kema Jia chromogenic medium. The susceptibility test was carried out by Kirby-Bauer method. 111 strains of Candida were observed on ECO, NYS, (ITR), ketoconazole (KET), fluconazole (FLU), 5-fluorocytosine (FCT) and amphotericin B (AMB). Results Among the 111 Candida species, Candida albicans was the most common species, accounting for 70.27%, followed by Candida tropicalis 21.62% and other Candida species 8.1%. Candida spp. The primary diseases were tumor, respiratory system, circulatory system, digestive system, hematological system, endocrine and urinary system diseases in turn. The sensitivity of Candida to antifungal drugs were nystatin, amphotericin B, Azole, 5-fluorocytosine, ketoconazole, fluconazole, econazole. Conclusion The fungal infection is closely related to the primary disease and aging. Rational use of antimicrobial agents to improve immunity is the main measure to prevent fungal infection in hospitalized patients.