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目的探讨一氧化氮、抗氧化剂、抗氧化酶与矽肺的关系。方法检测７３例矽肺患者和６０例健康对照者的血浆一氧化氮（Ｐ－ＮＯ）、维生素Ｃ（Ｐ－ＶＣ）、维生素Ｅ（Ｐ－ＶＥ）、β－胡萝卜素（Ｐ－β－ＣＡＲ）含量及红细胞超氧化物歧化酶（Ｅ－ＳＯＤ）、过氧化氢酶（Ｅ－ＣＡＴ）、谷胱甘肽过氧化物酶（Ｅ－ＧＳＨ－Ｐｘ）活性。结果与对照组比较，患者组的Ｐ－ＮＯ平均值显著升高（Ｐ＜０．００１），Ｐ－ＶＣ、Ｐ－ＶＥ、Ｐ－β－ＣＡＲ、Ｅ－ＳＯＤ、Ｅ－ＣＡＴ、Ｅ－ＧＳＨ－ＰＸ平均值均显著降低（Ｐ＜０．００１）；各检测值与患者病程、病情、肺功能状态均有相关；逐步回归表明患者病程、病情、肺功能状态与Ｐ－ＮＯ、Ｐ－ＶＥ、Ｅ－ＳＯＤ值相关最为密切。结论矽肺患者体内一氧化氮代谢异常，氧化抗氧化平衡严重失调，氧化和过氧化反应病理性加剧。
Objective To investigate the relationship between nitric oxide, antioxidants, antioxidant enzymes and silicosis. Methods The levels of plasma nitric oxide (P-NO), vitamin C (P-VC), vitamin E (P-VE) and β-carotene (P-β-CAR) were determined in 73 patients with silicosis and 60 healthy controls. Content and the activity of erythrocyte superoxide dismutase (E-SOD), catalase (E-CAT) and glutathione peroxidase (E-GSH-Px) Results Compared with the control group, the mean P-NO in patients was significantly higher (P <0.001), P-VC, P-VE, P-CAR, E-SOD, E-CAT (P <0.001). The measured values correlated with the course of disease, disease status and pulmonary function status. The stepwise regression showed that the patients’ course, state of illness, pulmonary function status and P-NO, P-VE , E-SOD values most closely related. Conclusion In patients with silicosis, the metabolism of nitric oxide is abnormal, and the balance of oxidation and anti-oxidation is seriously imbalanced. The pathological changes of oxidation and peroxidation are exacerbated.