Synthesis of Novel Monophosphoramidite Ligands Derived from L-Proline for Rh-catalyzed Asymmetric Hy

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Two novel monophosphoramidites were synthesized through a five-step transformation from commercially available L-proline. In the Ph-catalyzed asymmetric hydrogenation of α-dehydroamino acid derivatives, ligand (Sc,Ra)-1b showed good enantioselectivity and up to 91% e.e. was obtained.
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