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利用近红外光谱进行无创血糖检测时,人体自身状况的变化对测量结果的准确性造成非常大的影响.浮动基准法意在测量血糖的过程中寻找一个径向基准点,在这一位置处的漫反射光对葡萄糖浓度的变化不敏感,可以作为内部基准来消除各种背景变化的干扰.以intralipid溶液作为人体组织模拟液,用蒙特卡罗方法以及实验验证了径向基准位置的存在,并研究了不同光学参数对它的影响.模拟结果表明,1300nm波长下径向基准位置距光源1mm,且生物组织的散射特性对它的影响比吸收特性明显;设计的双光纤连续移动测量样品漫反射光能量的实验确认了模拟结果的正确性,证明了径向基准位置的存在.
The use of near infrared spectroscopy for non-invasive blood glucose testing, the changes in the body’s own condition on the accuracy of the measurement results have a very big impact.Floating reference method intended to measure blood glucose in the process of finding a radial reference point, at this position The diffuse reflected light is insensitive to the change of glucose concentration, which can be used as the internal reference to eliminate the interference of various background changes.With intralipid solution as human tissue simulation solution, the radial reference position is verified by Monte Carlo method and experiment The influence of different optical parameters was studied. The simulation results show that the radial reference position is 1mm away from the light source at the wavelength of 1300nm, and the influence of the scattering characteristics of the biological tissue on it is more obvious than the absorption characteristics. The experiment of light energy confirmed the correctness of the simulation results and proved the existence of radial reference position.