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环氧合酶-2(COX-2)是合成前列腺素的关键酶之一,其在组织细胞中呈诱导型表达。COX-2与肿瘤浸润转移具有一定相关性,其高表达可促进肿瘤转移.COX-2通过改变细胞表面粘着因子和细胞外基质、促进肿瘤血管生成以及改变肿瘤微环境等一系列病理生理变化促进肿瘤转移。COX-2已成为预防和阻止肿瘤转移的药靶,COX-2抑制剂对肿瘤有一定疗效。现就近年来COX-2在肿瘤浸润和转移中的作用及治疗研究作一综述。
Cyclooxygenase-2 (COX-2) is one of the key enzymes in the synthesis of prostaglandins and is inducible in tissue cells. COX-2 has a certain correlation with tumor infiltration and metastasis, and its high expression can promote tumor metastasis.COX-2 promotes a series of pathophysiological changes such as tumor angiogenesis and tumor microenvironment by altering cell surface adhesion factor and extracellular matrix tumor metastasis. COX-2 has become a target for the prevention and prevention of tumor metastasis. COX-2 inhibitors have a certain effect on tumors. Now in recent years the role of COX-2 in tumor invasion and metastasis and treatment research are reviewed.