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目的:探讨在妊娠早期行负压吸宫术前使用米索前列醇促宫颈成熟的适宜时间与剂量。方法:选择100例妊娠11-14周的健康女性,将其分为两组。在术前3h,研究组患者经阴道后穹窿给予米索前列醇0.6mg,对照组患者给予安慰剂,观察两组患者宫颈软化的情况。结果:米索前列醇阴道后穹窿给药的效果显著,2组患者手术时间的差异有统计学意义(P<0.05)。结论:用米索前列醇0.6mg术前3h阴道后穹窿给药是较合适的妊娠早期负压吸宫术前促进宫颈软化的方法。
Objective: To investigate the appropriate time and dose of misoprostol for cervical ripening before negative suction aspiration in early pregnancy. Methods: 100 healthy women of 11-14 weeks of pregnancy were selected and divided into two groups. In the preoperative 3h, patients in the study group were given misoprostol 0.6mg via the vaginal fornix, and patients in the control group were given placebo. Cervical softening was observed in both groups. Results: The effect of misoprostol on vaginal fornix was significant. The difference of operation time between the two groups was statistically significant (P <0.05). CONCLUSION: Administration of misoprostol 0.6 mg 3 h before vaginal fornix is a suitable method to promote cervical softening before vacuum abortion in early gestation.