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目的观察卡培他滨联合奥沙利铂治疗晚期胃癌的临床疗效以及不良反应。方法选取2008年8月-2010年10月期间本院收治的42例晚期胃癌患者采用卡培他滨联合奥沙利铂方案化疗,观察疗效及不良反应情况。结果本组患者化疗后疗效评价为CR2例,占4.76%;PR22例,占52.38%;有效率为57.14%;SD10例,占23.81%;PD8例,占19.05%。近期效果令人满意,不良反应以骨髓抑制、周围神经毒性、脱发以及消化道反应较为多见。讨论卡培他滨联合奥沙利铂治疗晚期胃癌疗效确切,不良反应较少,提高了胃癌晚期患者的生存质量,可以临床广为应用。
Objective To observe the clinical efficacy and side effects of capecitabine combined with oxaliplatin in the treatment of advanced gastric cancer. Methods Forty-two patients with advanced gastric cancer admitted to our hospital from August 2008 to October 2010 were treated with capecitabine combined with oxaliplatin chemotherapy. The curative effect and adverse reactions were observed. Results The efficacy of chemotherapy in this group was CR2 cases, accounting for 4.76%; PR22 cases, accounting for 52.38%; the effective rate was 57.14%; SD10 cases, accounting for 23.81%; PD8 cases, accounting for 19.05%. Recent results are satisfactory, adverse reactions to bone marrow suppression, peripheral neurotoxicity, hair loss and gastrointestinal reactions more common. Discussion Capecitabine combined with oxaliplatin in the treatment of advanced gastric cancer is effective, less adverse reactions, improve the quality of life of patients with advanced gastric cancer, can be widely used clinically.