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植物提取物鞣花酸是广泛存在于多种植物中的重要生物活性物质之一,阐述其药理作用、提取分离纯化及制剂研究具有非常重要的现实意义。本研究通过查阅近年来国内外文献,研究表明植物提取物鞣花酸具有抗氧化、抗肿瘤、抗菌等多种药理作用;通过酸解法辅助超声波、表面活性剂、响应曲面法等优化提高提取效率,兼有溶剂法、氧化法、生物酶法提取法;采用碱溶酸沉法、高效逆流色谱、大孔树脂吸附技术进一步分离与纯化得到生产原料;采用纳米技术研制纳米载体制剂,提高其在体内的生物利用度和延长作用时间,并对制剂的处方及工艺进行分析。以期为其扩大临床应用提供依据。
Plant extract Ellagic acid is one of the most important bioactive substances widely present in many kinds of plants. It is of great significance to elucidate its pharmacological action, extraction, isolation, purification and preparation research. In this study, we reviewed the literature at home and abroad in recent years, and the results showed that the ellagic acid extracted from plants has many pharmacological effects such as anti-oxidation, antitumor and antibacterial activity. The extraction efficiency is optimized by acid solution method such as ultrasonic, surfactant and response surface method , Both solvent method, oxidation method, biological enzymatic extraction method; using alkali-soluble acid precipitation, high efficiency countercurrent chromatography, macroporous resin adsorption technology to further separation and purification of raw materials obtained by the use of nanotechnology to develop nanocarrier formulations to improve its in In vivo bioavailability and extend the duration of action, and formulation of the formulation and process analysis. In order to provide the basis for its expansion of clinical applications.