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常用的四种抗心律失常药物作用的离子通道机制见左图。Ⅰ类药物能抑制快钠通道的钠内流,进而降低心肌细胞动作电位0相的快速除极(快钠通道)。Ⅱ类药物为β受体阻滞剂,其作用复杂,包括抑制4相动作电位舒张期的自动化除极过程,间接关闭钙通道使其在无腺苷酸环化酶的作用时,不能磷酸化而呈关闭状态。
The commonly used four anti-arrhythmic drug ion channel mechanism see the left. Class I drugs can inhibit the rapid sodium channel sodium influx, thereby reducing the cardiomyocyte action potential 0 phase rapid depolarization (fast sodium channel). Class II drugs are beta-blockers and their effects are complex, including an automated depolarization process that inhibits the diastolic phase of the 4-phase action potential and the indirect closure of the calcium channel to phosphorylation without the action of adenylate cyclase And was closed.