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目的 探讨1 3 1 I 抗癌胚抗原 (CEA)单抗防治裸鼠体内人结肠癌细胞肝转移的效果。方法 裸鼠脾内注入人结肠癌细胞后、脾切除后第 4或第 8d腹腔注射1 3 1 I 抗CEA单抗 ,观察术后生存时间 ,并对肝脏进行组织学检查。结果 术后第 4或第 8d注射1 3 1 I 抗CEA单抗均显著延长裸鼠术后生存时间 ;术后第 4d注射可使肝转移率减少 33 3% ,第 8d注射不能使肝转移率减少。结论 术后早期行放射免疫治疗可取得较好的治疗效果 ,放射免疫治疗尤其适合于肝微小转移癌的治疗
Objective To investigate the effect of anti-carcinoembryonic antigen (CEA) monoclonal antibody against liver metastasis of human colon cancer cells in nude mice. Methods Human colon cancer cells were injected into the spleens of nude mice. The mice were intraperitoneally injected with anti-CEA mAbs at the 4th or the 8th day after splenectomy. Survival time and histological examination of the liver were observed. Results The injection of 131I anti-CEA mAb on the 4th or 8th day postoperatively significantly prolonged the survival time of the nude mice. On the 4th day after the injection, the liver metastasis rate was reduced by 33.3% and the injection of the 8th day did not make the liver metastasis rate cut back. Conclusion Early postoperative radioimmunotherapy can achieve better therapeutic effect, radioimmunotherapy is especially suitable for the treatment of liver micrometastasis