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从青花椒中提取出的活性成分香柑内酯(Bergapten.Berg.),对小鼠的出血时间和出血量均有明显的减少作用,并能缩短小鼠的凝血时间(P<0.01);对于醋酸介导的小鼠毛细血管通透性有明显的抑制作用,与对照组比较有显著性差异(P<0.01);采用拉丁设计方法,对比研究Berg的止血作用,其结果表明,Berg对大鼠颈动脉和股动脉切口出血的止血率分别为88％和92％,显著优于纱布组(10％,15％)和淀粉组(15％,20％)。经X~2法、Fisher确切概率法和方差分析,差异显著(P<0.01)。
The active ingredient Bergapten.Berg., extracted from Zanthoxylum bungeanum, significantly reduced bleeding time and blood loss in mice, and shortened clotting time in mice (P<0.01). The inhibition of acetic acid-mediated permeability of mouse capillaries was significantly different from that of the control group (P<0.01). The Latin design method was used to compare the hemostatic effects of Berg. The results showed that the Berg pair The hemostasis rates of carotid and femoral arterial incisions in rats were 88% and 92%, respectively, which was significantly better than gauze (10%, 15%) and starch (15%, 20%). The differences were significant between the X~2 method, Fisher’s exact method, and analysis of variance (P<0.01).