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将72例初发T2DM患者随机分为瑞格列奈组(A组23例)、胰岛素组(B组25例)及胰岛素泵强化治疗组(C组24例),观察血糖、及胰岛B细胞功能的变化。结果A组B细胞功能的受损没有得到改善,c肽分泌峰值仍然较低而且后延,而C组c肽分泌峰均有提前,B细胞功能均有不同程度改善和恢复,但C组效果最好。结论胰岛素对初诊T2DM具有胰岛B细胞功能的作用。对于初发T2DM,应尽早采用胰岛素治疗。
72 patients with newly diagnosed T2DM were randomly divided into repaglinide group (A group, 23 cases), insulin group (B group, 25 cases) and insulin pump intensive treatment group (C group, 24 cases), observed blood glucose and islet B cells Functional changes. Results The damage of B cell function in group A was not improved, the peak of c peptide secretion was still low and delayed, while the peak of c peptide secretion in group C was earlier than that in group C. The function of group C was improved and recovered the best. Conclusion The effect of insulin on islet B cell function in newly diagnosed T2DM patients. For initial T2DM, insulin therapy should be used as soon as possible.