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分析了宣威肺癌高发区的370对核心家系的资料。结果表明;肺癌的发生具有家族聚集性,肺癌先证者的亲属患肺癌的危险性增加,是配偶家系亲属的1.85倍。女性亲属是配偶家系女性亲属的2.64倍。肺癌的遗传属于多基因遗传,其分离比为0.15,其遗传度为24.6%,肺癌先证者的亲属对肺癌的易感性比配偶的亲属高。遗传因素是肺癌的危险因素,但不是宣威肺癌高发的主要危险因素。
Analyzed the data of 370 core families in Xuanwei high incidence area of lung cancer. The results showed that the occurrence of lung cancer has family clustering, and the risk of lung cancer among relatives of lung cancer probands is increased by 1.85 times that of spouses’ relatives. Women’s relatives are 2.64 times that of spouses’ family members. The heredity of lung cancer belongs to multi-gene inheritance, the isolation ratio is 0.15, heritability is 24.6%, and the relatives of lung cancer probands are more susceptible to lung cancer than their spouses’ relatives. Genetic factors are risk factors for lung cancer, but they are not the main risk factors for the high incidence of Xuanwei lung cancer.