论文部分内容阅读
目的:探讨妊娠期糖尿病(GDM)母亲巨大儿及非糖尿病母亲巨大儿胰岛素和脂质运载蛋白-2水平的改变。方法:采用酶联免疫吸附法分别检测15例妊娠期糖尿病母亲分娩的巨大儿(GDM巨大儿组)、同期出生的17例非糖尿病母亲巨大儿(非GDM巨大儿组)和15例正常体重新生儿(对照组)血清胰岛素和脂质运载蛋-2的含量,并进行统计学分析。结果:与对照组相比,GDM巨大儿组、非GDM巨大儿组血清胰岛素和脂质运载蛋-2明显升高,差异有统计学意义(P<0.05);与非GDM巨大儿组相比,GDM巨大儿组血清胰岛素明显升高,差异有统计学意义(P<0.05),而GMD巨大儿组脂质运载蛋白-2虽有所升高,但无统计学意义。结论:GDM巨大儿和非(GDM)巨大儿均存在胰岛素和脂质运载蛋白-2的异常,因此,脂质运载蛋-2可能与巨大儿的发生、发展有一定关系。
Objective: To investigate the changes of insulin and lipocalin-2 levels in macrosomia and non-diabetic macrosomia in gestational diabetes mellitus (GDM) mothers. Methods: Enzyme-linked immunosorbent assay was used to detect the presence of giant GDM (GDM giant group) in 15 pregnant women with gestational diabetes mellitus, 17 non-diabetic giant mothers (non-GDM giant) and 15 normal newborn Children (control group) serum insulin and lipid-carrying protein-2 levels, and statistical analysis. Results: Compared with the control group, serum insulin and lipid-carrying-2 in the giant GDM group and the non-GDM giant group were significantly higher than those in the control group (P <0.05). Compared with the non-GDM giant group , GDM giant serum insulin significantly increased, the difference was statistically significant (P <0.05), while GMD macrophage lipoxygenase-2 although elevated, but not statistically significant. CONCLUSION: Both insulin receptor and lipocalin-2 are abnormal in GDM children with giant GDM, therefore, lipoxygenase-2 may be related to the occurrence and development of macrosomia.