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目的 探讨血管紧张素 (1 7) [Ang (1 7) ]在内皮素 1(ET 1)诱导血管平滑肌细胞增殖反应中的作用。方法 在ET 1诱导培养的SD大鼠主动脉血管平滑肌细胞模型中 ,应用Ang (1 7) ,通过测定3 H 胸腺嘧啶 (3 H TdR)掺入的方法 ,观察血管平滑肌细胞增殖情况。结果 Ang (1 7)呈剂量性抑制ET 1诱导血管平滑肌细胞的DNA合成 ,其作用受体不是血管紧张素Ⅱ受体 1(AT1)或血管紧张素Ⅱ受体 2 (AT2 ) ,而是通过一种特殊受体介导。结论 Ang (1 7)能抑制ET 1诱导的血管平滑肌细胞增殖。
Objective To investigate the role of angiotensin (1 7) [Ang (17)] in the proliferation of vascular smooth muscle cells induced by endothelin 1 (ET 1). Methods The proliferation of vascular smooth muscle cells was observed by measuring the incorporation of 3 H thymidine (3 H TdR) in the aortic vascular smooth muscle cells of SD rats induced by ET 1. Results Ang (17) dose-dependently inhibited ET 1 -induced DNA synthesis in vascular smooth muscle cells. The effect of Ang (17) was not that of AT1 or AT2, but of angiotensin II A special receptor mediator. Conclusion Ang (17) can inhibit the proliferation of vascular smooth muscle cells induced by ET 1.