临床和实验上脑缺血总是伴随着急性的炎症反应 ,脑缺血再灌注时中性粒细胞向内皮细胞粘附发生炎症反应 ,导致了粘附分子的上调 ,介导了与内皮细胞粘附并转移出血管壁 ,造成微血管和脑组织损伤并加重脑水肿。粘附分子是由一类由细胞产生 ,存在于细胞表面介导细胞间或细胞与间质 Both clinical and experimental cerebral ischemia is always accompanied by an acute inflammatory reaction. Inflammatory reaction of neutrophils to endothelial cell adhesion occurs during cerebral ischemia-reperfusion, leading to the up-regulation of adhesion molecules and mediating the adhesion to endothelial cells Attached and transferred out of the vessel wall, resulting in microvascular and brain tissue damage and increase cerebral edema. Adhesion molecules are produced by a class of cells that exist on the cell surface mediating intercellular or cell and interstitial