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目的研究血小板内游离钙离子浓度变化和高血压进程的关系以及口服单剂量卡托普利对高血压患者血小板内游离钙的影响。方法测定１０２例不同分期的原发性高血压患者静息血小板内游离钙浓度，其中５２例Ⅰ～Ⅱ期的轻中度高血压病人口服卡托普利２５ｍｇ，测定给药前和给药１ｈ后血压（ＢＰ）、血浆肾素活性（ＰＲＡ）、血管紧张素Ⅱ（ＡｎｇⅡ）和血小板内游离钙离子浓度（Ｃａ２＋）。结果原发性高血压患者静息血小板内Ｃａ２＋明显高于正常血压对照组。静息血小板内Ｃａ２＋和高血压分期有明显的相关性。静息血小板内Ｃａ２＋随高血压分期的增高而升高；口服单剂量卡托普利１ｈ后ＢＰ、血浆ＡｎｇⅡ水平和血小板内Ｃａ２＋明显降低，而血浆ＰＲＡ则明显升高。血浆ＡｎｇⅡ和血小板内Ｃａ２＋下降值之间（ｒ＝０．３７，Ｐ＜０．０１）及二者与平均压下降值之间均有弱的相关性（ｒ＝０．３８，ｒ＝０．３６，Ｐ＜０．０１）。血浆ＡｎｇⅡ和静息血小板内Ｃａ２＋之间无相关性。结论原发性高血压患者血小板处于激活状态，并和高血压进程相关。口服单剂量卡托普利可导致血小板内Ｃａ２＋下降。
Objective To investigate the relationship between platelet intracellular free calcium concentration and the progression of hypertension and the effects of oral single-dose captopril on platelet intracellular free calcium in hypertensive patients. Methods 102 patients with essential hypertension at different stages of the determination of resting platelet intracellular free calcium concentration, of which 52 cases Ⅰ ~ Ⅱ mild to moderate hypertensive patients taking captopril 25mg before and after administration of 1h Blood pressure (BP), plasma renin activity (PRA), angiotensin Ⅱ (AngⅡ) and intracellular free calcium concentration (Ca2 +). Results In patients with essential hypertension resting platelet Ca2 + was significantly higher than the normal blood pressure control group. Resting platelet Ca2 + and staging of hypertension have obvious correlation. Resting platelet Ca2 + increased with the increase of high blood pressure staging; oral administration of captopril alone 1h BP, plasma AngⅡ level and platelet Ca2 + decreased significantly, while plasma PRA increased significantly. There was a weak correlation between plasma AngⅡ and platelet Ca2 + decline (r = 0.37, P <0.01) and both mean pressure drop (r = 0.38, r = 0). 36, P <0.01). There was no correlation between plasma Ang II and resting platelet Ca2 +. Conclusion Platelets are activated in patients with essential hypertension and are associated with the progression of hypertension. A single oral dose of captopril can cause a drop in platelet Ca2 +.