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目的探讨头低位（－６°）卧床对人淋巴细胞增殖能力和某些细胞因子产生的影响。方法６名健康男性青年头低位（－６°）卧床６ｄ，卧床前１ｄ、３ｄ、６ｄ各采血一次，测定免疫指标。结果卧床３ｄ，α干扰素（ｉｎｔｅｒｆｅｒｏｎα，ＩＦＮα）产生明显降低（Ｐ＜０．０５），ＮＫ细胞（ｎａｔｕｒａｌｋｉｌｅｒｃｅｌ，ＮＫ）杀伤活性明显增强（Ｐ＜０．０５），γ干扰素（ｉｎｔｅｒｆｅｒｏｎγ，ＩＦＮγ）的产生和白细胞介素２受体（ｉｎｔｅｒｌｅｕｋｉｎ２ｒｅｃｅｐｔｏｒ，ＩＬ２Ｒ，又称ＣＤ２５）表达功能均呈降低趋势。卧床６ｄ，ＩＦＮα产生和ＮＫ杀伤活性均恢复至卧床前的水平，ＩＦＮγ产生和ＣＤ２５则明显降低（Ｐ＜０．０５）。随着卧床时间的延长，Ｔ淋巴细胞增殖能力和ＩＬ２的产生则逐渐降低，而ＩＬ６的产生则逐渐增加。结论头低位（－６°）卧床对细胞免疫功能有一定的影响。
Objective To investigate the effect of head depression (-6 °) on the proliferation of human lymphocytes and the production of some cytokines. Methods Six healthy male youths were admitted to the hospital for 6 days with low head (-6 °), 6 days before bed rest, and 1 day, 3 days and 6 days before bed rest respectively. Immune indexes were measured. Results The 3d, αinterferon (IFNα) production was significantly decreased (P <0.05) and the natural killer (NK) activity was significantly increased (P <0.05) interferonγ, IFNγ) production and interleukin 2 receptor (IL 2R, also known as CD25) expression showed a downward trend. Bed 6d, IFN α production and NK activity were restored to the level before bedtime, IFN γ production and CD25 was significantly lower (P <0.05). With prolonged bed rest, T lymphocyte proliferation and IL 2 production was gradually reduced, while the production of IL 6 is gradually increased. Conclusion Head depression (-6 °) has certain influence on cellular immune function.