目的对拉莫三嗪在中老年癫痫合并抑郁症治疗中的应用价值展开对比分析。方法将62例中老年癫痫合并抑郁症患者随机分为治疗组和对照组,各31例,对照组给予托吡酯。治疗组给予拉莫三嗪,比较治疗效果。结果治疗组患者治疗后癫痫平均发作次数、抑郁评分均显著低于对照组患者和治疗前(P<0.05);两组患者不良反应发生率和复发率分别为9.68%、0和32.26%、22.58%,比较两组患者不良反应发生率和复发率,差异有统计学意义(P<0.05)。结论在治疗中老年癫痫合并抑郁症临床上拉莫三嗪效果较为理想。 Objective To compare the value of lamotrigine in the treatment of middle-aged and elderly epilepsy with depression. Methods Sixty-two elderly patients with epilepsy and depression were randomly divided into treatment group and control group, with 31 cases in each group. The control group was given topiramate. The treatment group was given lamotrigine, the treatment effect was compared. Results The average number of epileptic seizures and depression in the treatment group were significantly lower than those in the control group and before treatment (P <0.05). The adverse reactions and recurrence rates in the two groups were 9.68%, 0 and 32.26%, 22.58 %, Comparing the two groups of patients with adverse reactions and recurrence rate, the difference was statistically significant (P <0.05). Conclusion The clinical efficacy of lamotrigine in the treatment of middle-aged and epilepsy with depression is ideal.