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目的探讨急性心肌梗死患者血浆骨保护素(osteoprotegerin,OPG)水平与近期预后的关系。方法125例住院患者分为灌注治疗组72例和非灌注治疗组53例及对照组53例,采用EL ISA法测定入院时和入院后14d血浆OPG水平。所有患者自入院起随访3个月。结果两组患者在入院时OPG水平均增高,但各组间比较差异无统计学意义(P>0.1)。入院第14天,灌注组OPG水平为(106.4±21.3)pg/ml,较入院时(223.5±59.8)pg/ml显著降低(P<0.05),而非灌注组前壁心肌梗死OPG水平(259.5±57.8)pg/ml反而较入院时(231.2±58.5)pg/ml增高,二者有显著性差异(P<0.05)。随访期间出现近期主要心脏不良事件(majoradverse cardiac events,MACE)的组入院时及第14天OPG水平与未发生MACE的组之间存在显著差异(P<0.05),提示OPG浓度与心肌梗死后近期MACE的发生明显相关。结论血浆OPG浓度是心肌梗死后早期心血管事件的预测因子,并有可能用于评估在急性心肌梗死患者中不同治疗方法的疗效。
Objective To investigate the relationship between plasma osteoprotegerin (OPG) level and prognosis in patients with acute myocardial infarction. Methods A total of 125 inpatients were divided into two groups: 72 patients in the perfusion group and 53 patients in the non-perfusion group and 53 patients in the control group. The levels of plasma OPG at admission and 14 days after admission were measured by ELISA. All patients were followed up for 3 months from admissions. Results The OPG levels of both groups increased at admission, but there was no significant difference between the two groups (P> 0.1). On the 14th day after admission, the level of OPG in the perfusion group was significantly lower (P <0.05) than that in the placebo group (106.4 ± 21.3) pg / ml (223.5 ± 59.8) pg / ml ± 57.8) pg / ml but higher than that at admission (231.2 ± 58.5) pg / ml. There was a significant difference between the two groups (P <0.05). There was a significant difference (P <0.05) between OPG level and MACE group on admission on the 14th day after the recent major adverse cardiac events (MACE) were observed in the follow-up period, suggesting that OPG concentration was significantly correlated with post-myocardial infarction The occurrence of MACE is obviously related. Conclusions Plasma OPG concentration is a predictor of early cardiovascular events after myocardial infarction and may be used to assess the efficacy of different treatments in patients with acute myocardial infarction.