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目的通过回顾性研究发现,福建省于2006年发生首例W135群流行性脑脊髓膜炎(流脑)病例,并对引起该病例的W135群脑膜炎奈瑟菌菌株进行病原学分析。方法对疑似流脑病例进行流行病学调查,脑脊液标本进行常规细菌培养,疑似菌株经生化鉴定和crgA基因及基因siaD(W135)PCR鉴定,Etest法进行药敏试验。结果该病例脑脊液标本分离到W135群脑膜炎奈瑟菌菌株,生化及PCR鉴定结果符合。该W135群菌株对头孢三嗪、头孢噻肟、利福平等9种抗菌药物均敏感。结论福建省2006年发现首例W135群流脑病例,回顾性研究发现,是近年来中国报道较少的W135群流脑病例。
OBJECTIVE: Through retrospective study, we found that the first W135 epidemic cerebrospinal meningitis (meningitis) occurred in Fujian Province in 2006 and etiological analysis of Neisseria meningitidis strain W135 in this case was made. Methods Epidemiological investigation of suspected cases of meningitis, cerebrospinal fluid samples of conventional bacterial culture, the suspected strains were biochemical identification and crgA gene and gene siaD (W135) PCR identification, Etest method for susceptibility testing. Results The samples of cerebrospinal fluid of this case were isolated from W135 serogroup Neisseria meningitidis. The results of biochemistry and PCR were consistent. The W135 strain was sensitive to 9 antibacterials including cefotaxime, cefotaxime and rifampicin. Conclusions The first case of W135 hermaphroditino was found in Fujian Province in 2006. The retrospective study found that cases of W135 hermaphroditra were rare in China in recent years.