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为了解二硫化碳（ＣＳ２）对肾上腺皮质功能的影响，探讨其作为ＣＳ２暴露生物监测指标的可行性及价值，采用ＨＰＬＣ法检测尿中皮质激素水平，并调查一组长期接触ＣＳ２的化纤生产工人血、尿中皮质激素及代谢产物的变化。结果表明接触超标浓度ＣＳ２的工人出现血、尿液皮质激素及代谢产物的减少。多元逐步回归分析表明肾上腺皮质激素的改变与空气ＣＳ２浓度密切相关。尿中皮质激素（游离皮质醇、可的松和醛固酮）以及代谢产物１７－酮类固醇可望成为反映肾上腺皮质功能状况的无损伤性生物监测指标。
To investigate the effect of carbon disulfide (CS2) on the adrenocortical function and to explore the feasibility and value of CS2 as a biological monitoring indicator of CS2 exposure, urine urinary corticosteroid levels were measured by HPLC and a group of long- Urinary corticosteroids and metabolites changes. The results showed that workers exposed to excessive concentrations of CS2 blood, urinary cortical hormones and metabolites decreased. Multivariate stepwise regression analysis showed that changes in adrenal cortex hormones and air concentration of CS2 are closely related. Urinary cortical hormones (free cortisol, cortisone and aldosterone), as well as the metabolite 17-keto-steroid, are expected to be noninvasive biological surveillance indicators that reflect adrenocortical functional status.