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目的：观察新型抗胆碱药长效托宁治疗急性有机磷农药中毒的效果。方法：急性有机磷农药中毒患者随机分为长效托宁治疗组与阿托品对照组，采用推荐剂量按轻、中、重分组治疗，并对其治疗效果进行比较。结果：长效托宁对不同中毒程度患者毒蕈碱样症状的控制疗效确实可靠，与对照组相比，达到阿托品化时间无明显差异（Ｐ＞０． ０５），但血清组织释放酶酶峰值、住院时间、住院费用及用药过量发生率均显著降低（Ｐ＜０ ．０５），尤其是给药次数极显著地减少（ Ｐ＜０． ００１）。对有机磷中毒昏迷病人昏迷时间及因胆碱能危象所致呼吸衰竭病人呼吸恢复时间均明显缩短（Ｐ（０ ．０５）。结论：长效托宁是救治急性有机磷农药中毒较为理想的抗胆碱药。
Objective: To observe the effect of new anticholinergic long-acting topin on acute organophosphorus pesticide poisoning. Methods: Acute organophosphorus pesticide poisoning patients were randomly divided into long-acting treatment group and atropine control group, using the recommended dose by light, medium and heavy treatment, and the treatment effect were compared. Results: The effect of long-acting topin on muscarinic-like symptoms in patients with different degrees of poisoning was reliable and reliable. Compared with the control group, there was no significant difference in atropisidine time (P> 0.05), but the peak value of serum tissue enzyme release (P <0 .05), hospitalization time, cost of hospitalization and medication overdose (P <0. 001), especially the number of administration decreased significantly (P <0.001). On organophosphate poisoning coma patients coma time and respiratory failure due to cholinergic crisis caused by respiratory failure were significantly shorter (P (0 .05) .Conclusion: Long-acting tonnage is ideal for the treatment of acute organophosphorus pesticide poisoning Anticholinergics.