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目的观察甘草酸二铵联合阿徳福韦酯治疗慢性乙型肝炎的疗效。方法将110例慢性乙型肝炎患者按随机对照原则分为两组,阿徳福韦酯治疗组50例,甘草酸二铵联合阿徳福韦酯治疗组60例,观察1年中肝功能恢复情况,HBV-DNA的转阴情况。结果B组肝功能恢复情况明显高于A组(P<0.01),两组HBV-DNA转阴率差异无统计学意义。结论采用甘草酸二铵联合阿徳福韦酯治疗慢性乙型肝炎,能使肝功能较快的恢复,肝脏炎性反应得到较迅速的清除,而且甘草酸二铵联合阿徳福韦酯治疗对HBV-DNA转阴无明显的不良反应。
Objective To observe the curative effect of diammonium glycyrrhizinate and adefovir dipivoxil on chronic hepatitis B. Methods One hundred and ten patients with chronic hepatitis B were divided into two groups according to the principle of randomized control: 50 cases were treated with adefovir dipivoxil, 60 cases were treated with diammonium glycyrrhizinate combined with adefovir dipivoxil, the recovery of liver function in 1 year, HBV-DNA negative situation. Results The recovery of liver function in group B was significantly higher than that in group A (P <0.01). There was no significant difference in the negative rate of HBV DNA between the two groups. Conclusions The treatment of chronic hepatitis B with diammonium glycyrrhizinate and adefovir dipivoxil can recover the liver function quickly and the inflammatory response of the liver can be cleared more rapidly. And the effect of diammonium glycyrrhizinate combined with adefovir dipivoxil on HBV- DNA negative no significant adverse reactions.