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Objective:To describe and assess the repair technique and perioperative management for cerebrospinal fluid (CSF) leak resulting from extensive anterior skull base fracture via extradural anterior skull base approach.Methods:This was a retrospective review conducted at the Department of Neurosurgery of the Shanghai Tenth People\'s Hospital from January 2015 to April 2020.Patients with traumatic CSF rhinorrhea resulting from extensive anterior skull base fracture treated surgically via extended extradural anterior skull base approach were included in this study.The data of medical and radiological records,surgical approaches,repair techniques,peritoperative management,surgical outcome and postoperative follow-up were analyzed.Surgical repair techniques were tailored to the condition of associated injuries of the scalp,bony and dura injuries and associated intracranial lesions.Patients were followed up for the outcome of CSF leak and surgical complications.Data were presented as frequency and percent.Results:Thirty-five patients were included in this series.The patients\' mean age was 33 years (range 11-71 years).Eight patients were treated surgically within 2 weeks;while the other 27 patients,with prolonged or recurrent CSF rhinorrhea,received the repair surgery at 17 days to 10 years after the initial trauma.The mean overall length of follow-up was 23 months (range 3-65 months).All the patients suffered from frontobasal multiple fractures.The basic repair tenet was to achieve watertight seal of the dura.The frontal pericranial flap alone was used in 20 patients,combined with temporalis muscle and/or its facia in 10 patients.Free fascia lata graft was used instead in the rest 5 patients.No CSF leak was found in all the patients at discharge.There was no surgical mortality in this series.Bilateral anosmia was the most common complication.At follow-up,no recurrent CSF leak or meningitis occurred.No patients developed mucoceles,epidural abscess or osteomyelitis.One patient ultimately required ven-triculoperitoneal shunt because of progressive hydrocephalus.Conclusion:Traumatic CSF rhinorrhea associated with extensive anterior skull base fractures often re-quires aggressive treatment via extended intracranial extradural approach.Vascularized tissue flaps are ideal grafts for cranial base reconstruction,either alone or in combination with temporalis muscle and its fascia-fascia lata sometimes can be opted as free autologous graft.The approach is usually reserved for patients with traumatic CSF rhinorrhea in complex frontobasal injuries.