本文报道以乙基纤维素为囊材，用液中干燥法制备阿莫西林-乙基纤维素微囊，药物包封率达60％以上。用转篮法对微囊及普通胶囊进行了体外溶出度考察，并用威布尔分布图治计法求得Td、T50、m参数，表明两种制剂的溶出度有显著差异（p＜0．01）.利用HPLC测定尿液中药物浓度，并进行药代动力学考察，Ka及K值亦存在显著性差异（P＜0．05）。 In this paper, ethyl cellulose was used as the encapsulation material to prepare amoxicillin-ethylcellulose microcapsules by liquid-drying method. The entrapment efficiency of the drug was above 60%. The in vitro dissolution of microcapsules and capsules were investigated by spin basket method, and Td, T50, m parameters were calculated by Weibull distribution method, indicating that the dissolution rates of the two preparations were significantly different (p <0.01 The drug concentration in urine was determined by HPLC, and the pharmacokinetic study was carried out. There was also significant difference between Ka and K (P <0.05).