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目的 :观察骨质疏松症骨骼中元素含量变化及其相互的关系。方法 :10月龄雌性 SD大鼠切除双侧卵巢(去卵巢模型组 ) ,并设假手术组 ,7个月后取胫骨 ,原子吸收分光光度法测定 Ca、P、Mg、Zn、Mn、Fe、Cu、Co、Mo和Cr含量 ,并对各元素的含量之间进行一元回归分析。结果 :骨质疏松症模型大鼠胫骨除 Ca、P和 Mg等常量元素分别下降 6 .6 % (P<0 .0 5 )、6 .3% (P<0 .0 5 )和 14 .9% (P<0 .0 1)以外 ,微量元素 Zn和 Fe分别下降 15 .2 % (P<0 .0 1)和 35 .1% (P<0 .0 1) ,Mo和 Cr分别下降 12 .2 % (P>0 .0 5 )和 14 .0 % (P>0 .0 5 ) ,而 Mn、Cu和 Co则无明显改变 ;Mg、Mn和 Zn等元素含量与 Ca、P经一元回归分析具有显著的相关性。结论 :去卵巢骨质疏松症模型大鼠骨骼 Ca、P、Mg、Zn和 Fe等含量明显下降。
Objective: To observe the changes of elements in osteoporosis bone and their mutual relations. METHODS: Female ovariectomized (OVX) model rats were excised from 10-month-old female Sprague-Dawley rats and sham-operated rats were sacrificed. The tibias were removed at 7 months and the contents of Ca, P, Mg, Zn, Mn and Fe were determined by atomic absorption spectrophotometry , Cu, Co, Mo and Cr content, and the content of each element between the one-way regression analysis. Results: In osteoporosis model rats, the constant elements such as Ca, P and Mg decreased by 6.6% (P <0.05), 6.3% (P <0.05) and 14.9 (P <0.01) and 35.1% (P <0.01), while the contents of Mo and Cr decreased by 12% .2% (P> 0.05) and 14.0% (P> 0.05), while the contents of Mn, Cu and Co did not change significantly. Regression analysis has significant correlation. Conclusion: The contents of Ca, P, Mg, Zn and Fe in skeletal bone of ovariectomized osteoporosis model rats decreased significantly.