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本文报道采用胃液多胺检测与胃镜活检普查相对照的方法,检测食管癌、胃癌高发区不同人群的胃液多胺水平。证实胃液多胺水平与食管或胃组织细胞的癌变程度有明显的平行关系,食管或胃上皮细胞受环境中有害物质长期刺激发生上皮细胞单纯增生时,胃液多胺含量升高27.08 ̄96.77%。阳性率36.36~55%;进而发展为不典型增生时,多胺含量明显增加,升高85.19 ̄198.69%阳性率66.67 ̄90.90%,癌变时胃液多胺含量升高4倍以上,阳性率均达100%.表明胃液多胺检测用以筛检潜在的无症状食管癌,胃癌和癌前期病人,是一种简便可行,灵敏准确的方法。
This article reported the use of gastric fluid polyamine detection and gastroscopy biopsy survey methods compared to detect esophageal cancer, high incidence of gastric cancer in different populations of gastric fluid polyamine levels. It was confirmed that the level of polyamine in gastric juice was significantly parallel to the degree of cancer in the esophagus or stomach tissue. When the esophageal or gastric epithelial cells were chronically stimulated by environmental harmful substances to produce epithelial cell proliferation, the content of polyamine in gastric juice was increased. 27.08 ̄96 .77%. The positive rate was 36.36-55%; when it developed into atypical hyperplasia, the polyamine content increased significantly, and the positive rate of 85.19 to 198.69% sputum was 66.67 to 90.90%. The content increased more than 4 times, the positive rate reached 100%. It is shown that gastric fluid polyamine detection is a simple, feasible, sensitive and accurate method for screening potential asymptomatic esophageal cancer, gastric cancer and precancerous patients.