Yunnan is located in the east margin of the collision zone between the India Plate and the Eurasian Plate on the Chinese Continent, where crustal movement is violent and moderate-strong earthquakes are frequent. In addition, the area features marked active block movement. Therefore, Yunnan is a perfect place for research on strong earthquake activity. Through the study on the temporal and spatial distribution of the M≥6.7 earthquakes and the related earthquake dynamics in Yunnan in the last century, we conclude that the four seismically active periods, which are characterized by alternative activity in the east and the west part of Yunnan, possibly result from a combination of active and quiescent periods in each of the east and west part. And for every 100 years, there may be a period in which strong earthquakes occur in the east and west parts simultaneously. In addition, the seismicity of strong earthquakes in Yunnan corresponds well to that in the peripheral region. The seismicity of the great earthquakes in the Andaman-Myanmar Tectonic Arc belt indicates, to some extent, the beginning of a seismically active period in Yunnan. The seismicity of strong earthquakes in east Yunnan is closely related to that in Sichuan. Strong earthquakes in Sichuan often occur later than those in Yunnan. Furthermore, in the east part of Yunnan, the three procedures including continuous occurrence of moderate-strong earthquake, quiescent period, and the occurrence of the first strong earthquake may be the style of the beginning of the earthquake active period. The above cognition is helpful to the study of earthquake prediction, seismogenic mechanism, and the dynamics of the plate margin in Yunnan. Yunnan is located in the east margin of the collision zone between the India Plate and the Eurasian Plate on the Chinese Continent, where crustal movement is violent and moderate-strong earthquakes are frequent. Thus, Through the study on the temporal and spatial distribution of the M ≧ 6.7 earthquakes and the related earthquake dynamics in Yunnan in the last century, we conclude that the four seismically active periods, which are characterized by alternative activity in the east and the west part of Yunnan, possibly result from a combination of active and quiescent periods in each of the east and west part. And for every 100 years, there may be a period in which strong earthquakes occur in the east and west parts simultaneously. In addition, the seismicity of strong earthquakes in Yunnan well well to that in the peripheral region. The seismicit y of the great earthquakes in the Andaman-Myanmar Tectonic Arc belt indicates, to some extent, the beginning of a seismically active period in Yunnan. The seismicity of strong earthquakes in east Yunnan is closely related to that in Sichuan. Strong earthquakes in Sichuan often occur later than those in Yunnan. Moreover, in the east part of Yunnan, the three procedures including continuous occurrence of moderate-strong earthquake, and the occurrence of the first strong earthquake may be the style of the beginning of the earthquake active period. The above cognition is helpful to the study of earthquake prediction, seismogenic mechanism, and the dynamics of the plate margin in Yunnan.