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目的探讨老年男性降钙素受体(CTR)基因型与骨密度(BMD)的关系,及其相应的健康教育方法。方法选取年龄≥70岁的深圳地区男性59例,采用双能X线骨吸收仪(DEXA)测定BMD值,并采用聚合酶链反应-限制性长度多态性(PCR-RFLP)技术检测CTR基因型。结果59例受试者中,CTR基因型分别为CC型47例(79.66%)、CT型12例(20.34%)、TT型0例;在腰椎2-4(L2-4)和沃氏三角(Ward’s)组BMD值,CT基因型组较CC型组低,差异有统计学意义(P<0.05),其他组间BMD值差异无统计学意义(P>0.05)。结论CT基因型的男性可能容易发生原发性骨质疏松(OP),尤其在L2-4和Ward’s部位;应及早实施具有个体化的健康教育,防治OP及避免OP性骨折的发生。
Objective To investigate the relationship between calcitonin receptor (CTR) genotypes and bone mineral density (BMD) in elderly men and their corresponding health education methods. Methods Fifty-nine male patients aged 70 years or older in Shenzhen were enrolled in this study. BMD was determined by DEXA, and the CTR gene type. Results Among the 59 subjects, the CTR genotypes were CC (47 cases, 79.66%), CT (12.34%) and TT (0), respectively. (Ward’s) group, the CT genotype group was lower than that of CC group (P <0.05), while there was no significant difference among other groups (P> 0.05). Conclusions Primary genotypes of osteoporosis (OP) are likely to occur in males with CT genotypes, especially in L2-4 and Ward’s sites. Individualized health education should be implemented as soon as possible to prevent OP and prevent the occurrence of OP fractures.