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目的探讨胆囊收缩素B受体(CCKB)在人正常组织及胰腺癌组织中的表达。方法运用免疫组化染色法检测CCKB受体在20例胰腺癌组织和4例正常胰腺组织中的表达与病理分级之间的关系。结果20例胰腺癌组织中CCKB受体有15例呈阳性表达,阳性表达率为75%,4例正常人胰腺组织CCKB受体全部呈阴性表达。不同病理学分级各组间CCKB受体阳性表达率无显著性差异(P均>0.05)。结论CCKB受体可能在肿瘤的发生发展过程中起一定的作用,也可用作胰腺癌临床诊断的有效生物学标志,并为胰腺癌的临床治疗提供了有效的靶受体。
Objective To investigate the expression of cholecystokinin B receptor (CCKB) in human normal tissue and pancreatic cancer. Methods The expression of CCKB receptor in 20 pancreatic cancer tissues and 4 normal pancreatic tissues was detected by immunohistochemistry. Results The CCKB receptor in 20 cases of pancreatic cancer was positive in 15 cases and the positive rate was 75%. The CCKB receptor in 4 cases of normal pancreatic tissue was all negative. There was no significant difference in the positive expression rate of CCKB receptor among different pathological grading groups (all P> 0.05). Conclusion CCKB receptor may play a role in tumorigenesis and development, and may be used as an effective biomarker for clinical diagnosis of pancreatic cancer. It provides an effective target receptor for the clinical treatment of pancreatic cancer.